What Is ARA-290?
ARA-290, also called cibinetide or pyroglutamate helix-B surface peptide, is an 11-amino-acid synthetic peptide modeled on the outward-facing region of erythropoietin helix B. It was designed to study non-erythropoietic signaling associated with an EPOR/CD131 receptor complex.
Overview
Researchers use ARA-290 to separate stress-response signaling from the classical erythropoietin-receptor pathway associated with red-blood-cell production. Cell and animal models have examined receptor dependence, inflammatory challenge responses, endothelial behavior, and sensory-neuron readouts.
In plain language, ARA-290 helps researchers ask whether one small part of erythropoietin can trigger a cell-stress response without using the main red-blood-cell signaling route.
History
ARA-290 emerged from efforts to map erythropoietin regions linked to tissue-response signaling without retaining the full hormone's canonical hematopoietic activity. The helix-B surface was reduced to a short peptide so that the proposed alternate receptor pathway could be tested directly.
Research Findings
- Biochemical records identify ARA-290/cibinetide as an 11-residue erythropoietin-derived peptide.
- Cell studies report binding and signaling associated with EPOR/CD131 rather than the canonical EPOR homodimer.
- Stress and inflammatory challenges can change CD131 surface expression and downstream transcriptional responses in experimental systems.
- Observed effects vary by cell type and injury model, and receptor dependence should be confirmed with blocking or genetic controls.
Documentation
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Use Restrictions
For Research Use Only. Not for human or veterinary use. Not a food, drug, cosmetic, dietary supplement, or household product. Fit Club Elite does not provide medical, dosing, mixing, reconstitution, administration, or end-use guidance. Purchasers are responsible for lawful handling, storage, and use in an appropriate research setting.