What Is MT-1 (Melanotan 1)?
Melanotan I, commonly associated with the alpha-MSH analogue afamelanotide, is a synthetic 13-amino-acid melanocortin peptide. Its Nle4 and D-Phe7 substitutions make it more stable than native alpha-MSH and support research focused primarily on MC1 receptor signaling.
Overview
Researchers use MT-1 in melanocyte and receptor models to study the cAMP pathway, pigment-related enzymes, oxidative-stress responses, and gene regulation downstream of MC1R. Compared with broader melanocortin ligands, it is often used when the research question centers on pigment-cell signaling and receptor-dependent cellular responses.
Researchers are interested in MT-1 because it offers a relatively focused way to study how MC1 receptor signaling changes pigment-cell behavior and stress-response pathways.
History
The Nle4,D-Phe7 alpha-MSH analogue was developed by University of Arizona researchers, including Victor Hruby and Mac Hadley, during melanocortin studies in the 1980s. The substitutions were designed to resist rapid breakdown while retaining melanocortin activity. The related pharmaceutical name does not replace the need to verify the identity and specifications of each research lot.
Research Findings
- Receptor and melanocyte assays have documented MC1R activation followed by cAMP/PKA pathway signaling.
- Cell studies measure changes in melanogenesis-associated enzymes and pigment-pathway gene expression.
- Experimental models have examined oxidative-stress, DNA-damage, and DNA-repair markers downstream of MC1R activation.
- Receptor response can vary with cell type, receptor expression, exposure conditions, and the comparator ligand used.
Documentation
Available analytical reports apply only to the exact product, strength, and lot identified on each report. A report for one strength or lot must not be assumed to cover another. Contact Fit Club Elite before ordering when a project requires lot-specific documentation.
Use Restrictions
For Research Use Only. Not for human or veterinary use. Not a food, drug, cosmetic, dietary supplement, or household product. Fit Club Elite does not provide medical, dosing, mixing, reconstitution, administration, or end-use guidance. Purchasers are responsible for lawful handling, storage, and use in an appropriate research setting.